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Computational simulations are conducted for several head impact scenarios using a three dimensional finite element model of the human brain in conjunction with accelerometer data taken from crash test data. Accelerometer data from a 3-2-2-2 nine accelerometer array, located in the test dummy headpart, is processed to extract both rotational and translational velocity components at the headpart center of gravity with respect to inertial coordinates. The resulting generalized six degree-of-freedom description of headpart kinematics includes effects of all head impacts with the interior structure, and is used to characterize the momentum field and inertial loads which would be experienced by soft brain tissue under impact conditions. These kinematic descriptions are then applied to a finite element model of the brain to replicate dynamic loading for actual crash test conditions, and responses pertinent to brain injury are analyzed.