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As part of the NASA Specialized Center of Research and Training for Advanced Life Support (NSCORT-ALS) at Purdue University, a complementary disinfection process, which uses ultraviolet (UV) radiation as the primary disinfectant and iodine as the secondary, residual disinfectant, is being developed. UV radiation was selected as the primary disinfectant because it is effective at inactivating a broad spectrum of microorganisms and has minimal potential for the formation of disinfection byproducts. Iodine, which is effective at inactivating many microorganisms and is less likely to react and form disinfection byproducts than other halogens, was selected as the residual disinfectant because it has the potential for dual use as an on-line UV monitor, as well as a disinfectant.