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Intersection crashes are a frequent and dangerous crash mode in the U.S. Emerging Intersection Advanced Driver Assistance Systems (I-ADAS) aim to assist the driver to mitigate the consequences of vehicle-to-vehicle crashes at intersections. In support of the design and evaluation of such intersection assistance systems, characterization of the road, environment, and drivers associated with intersection crashes is necessary. The objective of this study was to characterize intersection crashes using nationally representative crash databases that contained all severity, serious injury, and fatal crashes. This study utilized four national crash databases: the National Automotive Sampling System, General Estimates System (NASS/GES); the NASS Crashworthiness Data System (CDS); and the Fatality Analysis Reporting System (EARS) and the National Motor Vehicle Crash Causation Survey (NMVCCS).