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In applications ranging from design of customized vehicle interiors to virtual testing of biomedical devices, the processes of modeling, design and analysis involve the simultaneous treatment of artifacts (i.e., parts designed by humans) and anatomical structures. An inherent conflict arises because the geometric descriptions are completely different. Artifact descriptions are typically the output of computer-aided design (CAD) software and consist of a collection of parametric patches that comprise the boundary of the artifact. In stark contrast, the native description of an anatomical structure typically consists of an image stack obtained using a volumetric scanning technology such as computed tomography (CT) or magnetic resonance imaging (MRI). Current practice for simultaneously dealing with both categories of entities involves working primarily in the world of CAD.