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Pre-Crash Systems (PCS) integrate the features of active and passive safety systems to reduce both crash and injury severity. Upon detection of an impending collision, PCS can provide an early warning to the driver and activate automatic braking to reduce the crash severity for the subject vehicle. PCS can also activate the seatbelt pretensioners prior to impact. This paper identifies the opportunities for injury prevention in crash types for which PCS can be potentially activated. These PCS applicable crash types include rear-end crashes, single vehicle crashes into objects (trees, poles, structures, parked vehicles), and head-on crashes. PCS can benefit the occupants of both the striking and struck vehicle. In this paper, the opportunity for injury reduction in the struck vehicle is also tabulated. The study is based upon the analysis of approximately 20,000 frontal crash cases extracted from NASS / CDS 1997-2008.