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Traditionally radiation protection is left for evaluation after the completion of other engineering design processes followed by design changes to improve protection leading to off-optimum solutions of design problems. This project is a first attempt to develop optimization procedures with radiation constraint components from the beginning of the design process allowing performance optimization at reduced costs. The traditional limitation of radiation constraint analysis has been the slow computation time and the main focus thus far has been to apply high-performance computing to shielding analysis in preparation for MDO processes. We will describe the problem formulation, the framework for optimization, and progress towards developing highspeed computational procedures.