This paper presents the first results of an experimental study into a hybrid combustion concept for next-generation heavy-duty diesel engines. In this hybrid concept, at low load operating conditions, the engine is run in Pre-mixed Charge Compression Ignition (PCCI) mode, whereas at high load conventional CI combustion is applied. This study was done with standard diesel fuel on a flexible multi-cylinder heavy-duty test platform. This platform is based on a 12.9 liter, 390 kW heavy-duty diesel engine that is equipped with a combination of a supercharger, a two-stage turbocharging system and low-pressure and high-pressure EGR circuitry. Furthermore, Variable Valve Actuation (VVA) hardware is installed to have sufficient control authority. Dedicated pistons, injector nozzles and VVA cam were selected to enable PCCI combustion for a late DI injection strategy, free of wall-wetting problems.