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Metabolic heat regenerated temperature swing adsorption (MTSA) technology is being developed for removal and rejection of carbon dioxide (CO2) and heat from a portable life support system (PLSS) to the Martian environment. Previously, hardware was built and tested to demonstrate using heat from simulated, dry ventilation loop gas to affect the temperature swing required to regenerate an adsorbent used for CO2 removal. New testing has been performed using a moist, simulated ventilation loop gas to demonstrate the effects of water condensing and freezing in the heat exchanger during adsorbent regeneration. Also, the impact of MTSA on PLSS design was evaluated by performing thermal balances assuming a specific PLSS architecture. Results using NASA's Extravehicular Activity System Sizing Analysis Tool (EVAS_SAT), a PLSS system evaluation tool, are presented.