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Environmental Control and Life Support (ECLS) functionality aboard the International Space Station (ISS) includes responses to emergency conditions. The ISS requirements define three types of emergencies: fire, rapid depressurization, and hazardous or toxic atmosphere. The ISS has automatic integrated vehicle responses to each of these emergencies. These automated responses are designed to aid the crew in their response actions during the emergencies. This paper focuses on the ISS response to fire emergencies. It includes the integrated ISS automatic vehicle response and crew actions for fire. Philosophies covered include fire detection, fire response, and post-fire atmosphere recovery. Current responses and crew actions are discussed for the existing vehicle configuration on-orbit. This includes modules in the assembly sequence up to and including the Docking Compartment (DC1). Possible future improvements to the fire emergency responses are also described.