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This paper reviews a Crew Simulation Model (CSM) for Space Vehicle Integrative Life Support System (ILSS) operation study. It is designed to simulate crew metabolic reaction mass and energy flows in accelerated time mode with each crew member specifics consideration. This CSM formally is based on human body general simulation, which includes main functional systems like: the cardiac-vascular, external respiration, thermal regulation and water/mineral balance. Work and rest time schedules are also considered as well as each crew member presence in a particular module. The CSM considers trace contaminants in metabolic products due to nutrition and environment temperature. This simulations' formal review is shown in the paper as well as formal implementation with computed experiment results. Some of the possible applications are also approached.