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It is well known that selection of the pressure/oxygen ratio for a human space habitat is a critical decision for the well-being and mission performance of astronauts. It has also been noted how this ratio affects the requirement for pre- and post-breathing and the type and flexibility of EVA/EHA astronaut suits. However, little attention has been paid to how these issues interact with various mission design strategies. Using the first manned mission to Mars as a baseline mission, we have separated the mission into its component parts as it relates to habitat type (i.e., the Earth-Mars interplanetary vehicle, the ascent/descent vehicle, the base, human rover vehicles, etc.) and have determined the oxygen resupply requirements for each part as they reflect a mission design strategy. These component parts form a matrix where duration of stay, loss of oxygen due to leakage and usage, and oxygen resupply needs are calculated.