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Motion sickness in road vehicles may become an increasingly important problem as automation transforms drivers into passengers. Motion sickness could be mitigated through control of the vehicle motion dynamics, design of the interior environment, and other interventions. However, a lack of a definitive etiology of motion sickness challenges the design of automated vehicles (AVs) to address motion sickness susceptibility effectively. Few motion sickness studies have been conducted in naturalistic road-vehicle environments; instead, most research has been performed in driving simulators or on motion platforms that produce prescribed motion profiles. To address this gap, a vehicle-based experimental platform using a midsize sedan was developed to quantify motion sickness in road vehicles. A scripted, continuous drive consisting of a series of frequent 90-degree turns, braking, and lane changes were conducted on a closed track.