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Occupational populations have become increasingly diverse, requiring novel accommodation technologies for inclusive design. Hence, further attention is required to identify potential differences in work perception between workers with varying physical limitations. The major aim of this study was to identify differences in shoulder loading and perception of effort between a control population (C) and populations affected by chronic back pain (LBP) and spinal cord injury (SCI) in one-handed seated transfer tasks to targets. The effects of the injuries, and associated pain, are likely to produce variations in movement patterns, muscle loading and perceived effort.