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Biomechanics and biodynamics are increasingly focused on the automotive industry to provide comfortable driving environment, reduce driver fatigue, and improve passenger safety. Man-centered conception is a growing emphasis on the open design of automobile. During the long-term driving, occupational drivers are easily exposed to the neck pain, so it is important to reduce the muscle force load and its fatigue, which are not usually considered quantitatively during traditional ergonomics design, so standards related are not well developed to guide the vehicle design; On the other hand, the head-neck models are always built based on the statics theory, these are not sufficient to predict the instantaneous variation of the muscle force. In this paper, a head-neck model with multi DOFs is created based on multibody dynamics. Firstly, a driver-vehicle-road model considering driver multi-rigid body model, vehicle subsystems, and different ranks of pavement is built.