In this paper, a further step along a research line concerning the set up of a Fault Diagnosis system for OBD-II purpose is presented. The suitability of Artificial Neural Networks for the use as engine simulation modules in the framework of a software redundancy approach has been analyzed. Experimental tests were performed, by acquiring four main engine operational parameters. Using this knowledge base, the performance of a wide variety of different Net Types was analyzed and discussed. Peculiar aspects of the possible industrial applications of this methodology are also deeply examined.