This paper presents an Axiomatic Design framework for manufacturing system design and illustrates how lean cellular manufacturing can achieve volume flexibility. Axiomatic Design creates a design framework by mapping the functional requirements of a system to specific design parameters. Volume flexibility is often neglected as a requirement of manufacturing systems. Very few industries are fortunate enough to experience stable or predictable product demand. In reality, demand is often volatile and uncertain. It is important that manufacturing system designers are aware of manufacturing system types which can accommodate volume flexibility and follow a structured design methodology that assures that all requirements are met by the system.