Vibration and sound radiation characteristics of bead-stiffened panels are investigated. Rectangular panels with different bead configurations are considered. The attention is focused on various design parameters, such as orientation, depth, and periodicity, and their effects on equivalent bending stiffness, modal density, radiation efficiency and sound transmission. A combined FEA-SEA approach is used to determine the response characteristics of panels across a broad frequency range. The details of the beads are represented in fine-meshed FEA models. Based on predicted surface velocities, Rayleigh integral is evaluated numerically to calculate the sound pressure, sound power and then the radiation efficiency of beaded panels. Analytical results are confirmed by comparing them with experimental measurements. In the experiments, the modal densities of the panels are inferred from averaged mechanical conductance. The radiated sound power and radiation efficiency are measured by using surface intensity scan. Analytical predictions are compared with experimental results for different bead configurations. The study is concluded with a set of guidelines for design of beads on automobile floor panels.