In this paper, an advanced trace gas monitoring system for manned space cabins is presented. The principle of functioning of the measurement system is based on the detection of gas-specific absorption features in the Infrared area of the spectrum. The core element in the monitoring system is a Fourier-Transform Infrared (FTIR) Spectrometer. When calibration is carried out applying sophisticated, novel analysis methods, the system can simultaneously detect and quantify all the interesting gases in manned space cabins.In a previous Trace Gas Monitoring multi-phase program (TGM 2) ,, the FTIR technology has demonstrated its ability to handle multi-component, quasi on-line gas measurements, including identification and quantification of 23 important trace gases in a mixture. In the ongoing phase 3 (TGM 3), initiated end of 1997 , a fully operational FTIR technology demonstration model is tested being able to detect simultaneously 30 different trace gases in a mixture.For coverage of air analyses in multi-module spacecraft, an additional monitoring strategy has been worked out - a complete spacecraft monitoring system. In the spacecraft, small and lightweight enrichment systems and Smart Gas Sensor detection systems (artificial nose) are distributed covering measurements with extremely low detection limits as well as measurements for immediate warning on local changes in the cabin air.