Until recently, the application of the detailed chemistry approach as a predictive tool for engine modeling has been sort of a “taboo” for different reasons, mainly because of an exaggerated rigor to the chemistry/turbulence interaction modeling. In terms of this ideology, if the interaction cannot be simulated properly, the detailed chemistry approach makes no sense. The novelty of the proposed methodology is the coupling of a generalized partially stirred reactor, PaSR, model with the high efficiency numerics to treat detailed oxidation kinetics of hydrocarbon fuels. In terms of this approach, chemical processes are assumed to proceed in two successive steps: the reaction follows after the micro-mixing is completed on a sub-grid scale. Recent experimental observations on soot formation made in  and  are perfectly reproduced in the modeling, when the mechanism integrating reduced, but still comprehensive, n-heptane oxidation chemistry with kinetics of aromatics formation (see ) has been used in the simulation based on the new numerical approach incorporated into the KIVA-3 code. Finally, the model has been applied to simulation of the turbocharged Volvo AH10A245 and D12C DI Diesel engines, and the results are discussed. The soot reduction effect attributed to a shortening of fuel injection duration has been validated in the modeling.