In this case study, a human factors analysis was carried out in the preliminary design phase of the Cupola, a European Space Agency (ESA) module for manned space flights for the International Space Station (ISS). The manikin software Jack® was used early in the design process before any flight hardware production. All Cupola astronaut tasks were evaluated in a virtual environment of the Cupola. Methodological aspects concerning the analysis are described, e.g. file processing, use of coordinate systems and the use of a prior task analysis. Results show that the thorough manikin analysis supported with the hierarchical task analysis results, was an important help in the design process.