The maximal capability of several body areas to absorb/release heat by varying the circulating water temperature in different zones of a multi-compartment liquid cooling/warming garment (LCWG) was explored. The goal was to identify the areas that are highly effective to stabilize body comfort, and to use this information for developing a more physiologically-based design of the space suit. The results showed a high capability of the upper compared to the lower body in the conductive heat exchange process. The involvement of the head in this process is still problematic, because there was not a high level of direct heat absorption/release through the cooling/warming hood in the LCWG. Exclusion of the legs but with involvement of the feet in heat exchange had no effect on comfort of the distal parts of the extremities and core body status.