We report a chemical sensing technology composed of engineered bioluminescent bacteria placed on an integrated microluminometer. The bacteria have been engineered to luminesce when the targeted compound is metabolized, while the microluminometer detects, processes, and then reports the magnitude of this optical signal. In this work we report our progress in the development of these biosensors and present data from our prototypes.
Citation: Simpson, M., Paulus, M., Jellison, G., Sayler, G. et al., "Bioluminescent Bioreporter Integrated Circuits (BBICs): Whole-Cell Environmental Monitoring Devices," SAE Technical Paper 2000-01-2420, 2000, https://doi.org/10.4271/2000-01-2420. Download Citation
Michael L. Simpson, Michael J. Paulus, Gerald E. Jellison, Gary S. Sayler, David E. Nivens, Hebe M. Dionisi, Steven Ripp, Bruce M. Applegate, Greg Patterson, Eric Bolton, Chris Arnott, James Rochelle
Oak Ridge National Laboratory, University of Tennessee Center for Environmental Biotechnology, University of Tennessee Dept. of Electrical and Computer Eng.
International Conference On Environmental Systems