The design of hypersonic vehicles is influenced by tightly coupled interactions between aerodynamics, propulsion, and structures. Therefore, in the conceptual design phases, the identification and mitigation of potential problem areas and disciplinary interrelations are critical. Although the multidisciplinary character of hypersonic designs is well known, research in hypersonics is primarily focused on the isolated disciplines with side notes on the interactions. The designer has to integrate all the disciplinary information and create a successful system. This integration is a tedious and elaborate process involving time-consuming iterations.This paper proposes a new approach and entails the creation of Response Surface Equations from the various constituent disciplines considered. This method allows to quickly assess the implication of design decisions at the top level using the multiple disciplinary meta-models. As an exercise, the paper demonstrates the generation of a structural meta-model for a hypersonic strike fighter that must fulfill certain mission requirements.