Today, electrical/electronic systems like ABS/power brakes and electric power steering are all designed to enhance, not replace a mechanical function. If an electrical or electronic fault occurs, the function reverts to the base mechanical capability. Future E/E systems, such as steer-by-wire and brake-by- wire replace mechanical linkages with electrical or optical signals as in computer networks. While these systems offer many potential safety benefits, they will require different strategies for dependability, and as with any vehicle system, they will further require that dependability be an integral part of the overall E/E system design. This paper illustrates how by-wire systems drive different dependability requirements and discusses some key technologies that are emerging to meet these requirements.