The paper compares Road Racing World Championship Grand Prix (WGP) engine solutions developed in compliance with the 2002 Federation Internationale de Motocyclisme (FIM) Technical Regulations. Ad-hoc assumptions, similarity rules and nondimensional parameters from previous projects are used to define geometric and operating parameters for partly similar engine solutions basically differing in the number of cylinders, three, four, five or six, and the cylinder layout, in-line or V-angle. Results are shown as computed classical engine outputs versus engine speed, including brake, indicated and friction values. By increasing the number of cylinders, charging efficiency reduces, while thermal efficiency increases. Higher values of brake torque and power and lower values of brake specific fuel consumption are provided by the V-angle six cylinder engine. By using the smallest engine cross section, the sharpest motorcycle acceleration and the minimum weight of motorcycle as engine selection criteria, the V-angle five cylinder engine reaches the highest score.