Evolutionary Operation (EVOP) experimental design using Sequential Simplex method is an effective and robust means for determining the ideal process parameter (factor) settings to achieve optimum output (response) results. EVOP is the methodology of using on-line experimental design. Small perturbations to the process are made within allowable control plan limits, to minimize any product quality issues while obtaining information for improvement on the process. It is often the case in high volume production where issues exist, however off-line experimentation is not an option due to production time, the threat of quality issues and costs. EVOP leverages production time to arrive at the optimum solution while continuing to process saleable product, thus substantially reducing the cost of the analysis. Sequential Simplex is a straightforward EVOP method which can be easily used in conjunction with prior traditional screening DOE or as a stand-alone method to rapidly optimize systems containing several continuous factors.