In this work we discuss some types of simulation environments and laboratories, their characteristics and applications to the simulation and control of aerospace vehicles. This includes: the basic definitions, types and characteristics of simulators and simulations (physical, computational, hybrid, etc.; discrete events, discrete time, continuous time, etc; deterministic, stochastic, etc.) their basic compromise (simplicity × fidelity), their man-machine interfaces and interactions (virtual, constructive, live, etc.), their evolution law (time, events, mixed, etc.), their architectures (“stand-alone”, PIL, HIL, MIL, DIS, HLA, etc.), and especially, their environments (discrete, continuous, hybrid, etc.) and laboratories (physical, computational, hybrid, etc.), and their applications to the simulation and control of aerospace vehicles. This is illustrated by some examples driven from the aerospace industry.