A diesel combustion model for CFD simulation is established taking into account the auto-ignition process of a non-homogeneous mixture. In a previous paper, the authors revealed that the non-homogeneity of a fuel-air mixture has a more significant effect on the auto-ignition process with respect to, for example, ignition delay or combustion duration, as compared to the turbulent mixing rate. Based on these results, a novel diesel combustion model is proposed in the present study. The transport calculation for the local variation of the fuel-air PDF is introduced, and the chemical reaction rate is obtained based on the local non-homogeneity. Furthermore, this model incorporates RANS-based CFD simulation of the spray combustion in a constant-volume vessel under a high-temperature, high-pressure condition. The results show that the combustion process is well described for a wide range of temperature and pressure conditions.