The application of stability systems on heavy vehicles clearly has numerous advantages, when the cost of the cargo, the service life of vehicles, and the vehicle potential for damage are taken into account. The primary objective of such systems is to assist the driver to maintain control in the face of uncertain driving conditions. The dynamic effects of such system, however, are not widely tested by the industry. The study presented in this paper will present an evaluation of the effects of full and partial stability systems on tractor-trailers using hardware-in-the-loop simulation. With the advancement of simulation capabilities that enables the repeatability of maneuvers, the study presented attempts to provide various deterministic “what-if” scenarios under various vehicle stability system combinations.