The U.S. Environmental Protection Agency instrumented and tested a line-haul Class 8 tractor trailer on a 4-wheel-drive heavy-duty chassis dynamometer. A vehicle model was then developed in the Powertrain Systems Analysis Toolkit (PSAT), Argonne National Laboratory's vehicle simulation tool, using the truck technical specifications and the recorded data, which included the Portable Emissions Measurement System (PEMS) and Controller Area Network (CAN) signals. In this paper, we describe the test scenarios and the analysis performed on the data. We then present the vehicle model and assumptions. Finally, we compare the test and simulation data, including fuel consumption and component signals, as well as the main challenges specific to heavy-duty vehicle testing and simulation.