Predicting AHSS cracking during crash events and forming processes is an enabling technology for AHSS application. Several fracture criteria including MatFEM and Modified Mohr-Coulomb Criterion were developed recently. However, none of them are designed to cover more fracture modes such as bending fracture and tearing fracture with initial damage. A mixed-mode fracture criterion (MMFC) is proposed and developed to capture multiple fracture modes including in-plane shearing fracture, cross-thickness shearing fracture with bending effect and tearing fracture with initial damage. The associated calibration procedure for this criterion is developed. The criterion is implemented in a commercial FEA code and several lab validations are conducted. The results show its promising potential to predict AHSS cracking at large strain conditions.