In recent years, products that make use of integrated safety that use the environmental data to optimize occupant restraints have been on the market. Pre-safe system in the integrated safety category is an adaptive and smart protection system that utilizes the occupant information and the monitoring information on the accident prediction.These pre-safe systems need the proper algorithm corresponding to the crash scenario for the crash unavoidable state. Due to the crash scenario categories for the real world accidents is quite various, the development of the algorithm and the occupant protection system to reduce the injury is quite complex and costly. For this reason, a development process for pre-safe related integrated safety systems demands new tools based on the biomechanics to help design and assessment.The virtual development and assessment process with a viewpoint on the efficiency of the restraint development has been developed. The real time controlled restraint system (MADYMO-SIMULINK Coupling) is adapted for support this process. The virtual development process with real time controlled restraint system offers an optimized guide line in terms of injury reduction over various crash scenarios. With this virtual development process, definition of the proper restraint characteristics and the algorithm for the various crash scenarios can be achieved more easily and fast.The effectiveness of this process is evaluated and the obtained restraint characteristics will be used as a basis to define the appropriate integrated safety features and the performance criteria.