Numerical simulations are performed to investigate noise generated by flow in automotive HVAC ducts. A hybrid computational method for analyzing flow noise is applied: Large Eddy Simulation (LES) for predicting flow fields and Multi-domain boundary element method for predicting acoustic propagation. LES gives time-resolved solutions of flow velocity and pressure fields. By applying the acoustic analogy theory, the unsteady flow parameters are translated into sound source in evaluating the acoustic propagation. The computational result shows the noise caused by the HVAC ducts is strong. The noise is of broadband with a peak value at 370Hz. A major contribution of the noise generation is from the center ducts. Two design modifications of the center ducts are explored to regulate the flow structures with the ducts for reducing noise generation. Test results demonstrate the effectiveness of the modifications.