It is well known that sound radiation from a rectangular panel can be significantly affected by its boundary condition. However, most of the existing investigations are primarily focused on sound radiation from plates with simply supported boundary conditions. The objective of this paper is to study the effect on sound radiation of the boundary supporting conditions generally specified in the form of discrete and/or distributed restraining springs. This will have practical implications. For example, in automotive NVH design, it is of interest to understand how the sound radiation from a body panel can be affected by the number and distribution of spot-welds. It is demonstrated through numerical examples that the distribution of spot-welds can be tuned or optimized, like other conventional design parameters, to achieve maximum sound reduction.