In this study, an investigation was made on a heavy duty diesel engine using both conventional diesel combustion mode and a partially premixed combustion (PPC) mode. A segment mesh was built up and modeled using the commercial CFD code AVL FIRE, where only the closed volume cycle, between IVC and EVO, was modeled. Both combustion modes were validated using experimental data, before a number of heat flux boundary conditions were applied. These conditions were used to evaluate the engine response in terms of engine performance and emission levels for the different percentage of heat rejection. The engine performance was measured in terms of specific fuel consumption and estimated power output, while the calculated net soot and accumulated NOx mass fractions were used for comparing the emission levels. The results showed improved efficiency for both combustion types, but only the PPC combustion mode managed that without increasing the production of NOx emissions severely.