This paper investigates the effects of Fischer-Tropsch Diesel (FTD) (a completely a paraffinic fuel) on the fuel supply system in automotive applications. In particular, the effects of Gas to Liquid (GTL) (an FTD synthesized from natural gas) on the elastomer components has been investigated by laboratory scale tests and field trials. In the field trials, GTL was supplied to a commercial vehicle operator and the effect of real running conditions was observed. Also, the laboratory scale testing to simulate the actual condition of usage of a commercial vehicle was conducted under stringent conditions, and a correlation with the field trials was investigated. As a result, no negative effects related to GTL were found.