In this study, the technology that can predict fatigue life for motorcycle exhaust systems is developed. To predict the fatigue life, analyzing the engine vibration, modeling the vibration characteristics of exhaust systems and evaluating the fatigue damage of welded joints are considered essential. This paper shows an integrated numerical simulation and evaluation method. Furthermore, it is also shown with the result of a component vibration test of the muffler assembly to validate the technology. The results indicate a good correlation between the numerical simulation and the test.