Cycle-to-cycle variations of combustion processes strongly affect the emissions, specific fuel consumption as well as work output. Especially Direct Injection Spark-Ignition (DISI) engines are very sensitive to cyclic fluctuations within the combustion chamber. Multi-cycle Large Eddy Simulation (LES) based analysis has been used for investigating unsteady effects of spray combustion processes and misfires. A realistic four-stroke DISI internal combustion engine configuration was taken under consideration. The effects of variable spray boundary conditions on spray combustion are discussed first. A qualitative analysis of the intensity of cycle-to-cycle variations of in-cylinder pressure is presented for various combinations of injection parameters and ignition points. Finally, the effect of ignition probability and analysis of misfires are pointed out. The described above processes were discussed in terms of mean and standard deviation of temperature, velocity and pressure.