The causes of injuries suffered by drivers in “small-overlap frontal crashes” (SOFC) were examined. These crashes were defined as ones in which vehicles are loaded outside their longitudinal side members. SOFC accident data sets stored in the National Automotive Sampling System-Crashworthiness Data System (NASS-CDS) database were investigated. Percentages of cases sustaining injury to each body region of drivers were calculated, and the differences between the percentages of injury by body region were examined. To investigate the injury mechanisms, SOFC tests with two types of rigid barrier were then conducted. Injury values in each body region were analyzed to validate the reproducibility of SOFC test as a relevant test.