Due to the integration of many interacting subsystems like hybrid vehicle management, energy management, distance management, etc. into the VCU platform the design steps for function development and calibration become more and more complex. This makes an aid necessary to relieve the development. Therefore, the aim of the proposed simulation-based development and calibration design is to improve the time-and-cost consuming development stages of modern VCU platforms. A simulation-based development framework is shown on a complex function development and calibration case study using an advanced powertrain concept with a plug-in hybrid electric vehicle (PHEV) concept with two electrical axles.