This paper describes how we predict the stress of engine components resulting from vibration of engine, using MBD (Multi Body Dynamics) and FEA (Finite Element Analysis). In a development of industrial engine, many engine models which are installed on various machines are developed. Depending on operating condition of machine, many kinds of components are designed. Therefore, in order to shorten a development period, it is important to predict accurately stress of components and evaluate its durability in the design phase. In this study, for exhaust silencer, the stress of engine components which are caused from of engine vibration is calculated by FEA and MBD and the accuracy of prediction is confirmed as compared with the experiment result. In addition, the stress of oil suction pipe is predicted. As vibrational characteristic of oil suction pipe is influenced by lube oil, virtual mass method is used in order to take into consideration the influence of fluid which is surrounding it. Finally, the fatigue life of component can be predicted for each machine, using operating data of machine which the engine is installed on. In this method, suitable engine components for each machine can be designed in the design phase.