A rough road ride assessment provides an insightful evaluation of vehicle responses beyond the frequency range of suspension or steering modes. This is when body structure influence on the vehicle performance can be detected by vehicle occupants. In this paper, a rough road is used to evaluate vehicle ride performance and multi-body simulation (MBS) models are developed along with finite-element (FE) representations of the vehicle body and structure. To produce high fidelity simulation results in the frequency range of interest, various vehicle subsystem modeling contents are examined. A case study of a vehicle model with two different structures is provided. Time histories and frequency based analyses are used to obtain insights into the effects of body structure on vehicle responses. Finally, two metrics (‘Isolation’ and ‘Shake’) are used to distinguish the vehicle ride performance.