A comprehensive analysis was performed to evaluate the effect of BMI on different body region injuries for side impact. The accident data for this study was taken from the National Automotive Sampling System-Crashworthiness Data System (NASS-CDS). It was found that the mean BMI values for driver and front passengers increases over the years in the US. To study the effect of BMI, the range was divided into three groups: Thin (BMI<21), Normal (BMI 24-27) and Obese (BMI>30). Other important variables considered for this study were model year (MY1995-99 for old vehicles & MY2000-08 for newer vehicles), impact location (side-front F, side-center P & side-distributed Y) and direction of force (8-10 o'clock for nearside & 2-4 o'clock for far-side). Accident cases involving older occupants above 60 years was omitted in order to minimize the bone strength depreciation effect. Results of the present study indicated that the Model Year has influence on lower extremity injuries. Occurrence of pelvis injury was found to be influenced by BMI and was validated with logistic regression analysis. Apart from BMI, gender and age may have prominent effect on lower extremity injuries. Percentage of thorax injury and abdomen injuries appeared to be less for the thin people group (BMI<21), which has to be validated in the future by appropriate statistical methods.