The aim of the study was to investigate the difference between car-to-e-bikes and car-to-pedestrian accidents. The China In-depth Accident Study (CIDAS) database was searched from 2011 to 2013 for pedestrians and e-bikes struck by car, van and SUV fronts, which resulted in 104 pedestrian and 85 e-bike cases where information was sufficient for in-depth analysis. Reconstruction by PC-Crash was performed for all of the sampled cases. Pre-crash parameters were calculated by a MATLAB code. Focus was on prototypical accident scenarios and causes; speed as well as possible prevention countermeasures. It has been shown that traffic light violations, road priority violations, and unsure safety (these situations included misjudgments, unpreparedness, proximity to other road users, inappropriate speeds, etc.…) are the main causes in both the VRU groups. Distinctions were found for aspects of car collision speed, accident scenario, distribution of head contact points and so on. Pre-impact braking/warning systems could help drivers take pre-crash measures and mitigate crash severity, but a larger field of view (FOV) for sensors is of greater necessity for e-bikers than for pedestrians.