This works presents a real-time capable simulation model for dual fuel operated engines. The computational performance is reached by an optimized filling and emptying modeling approach applying tailored models for in-cylinder combustion and species transport in the gas path. The highly complex phenomena taking place during Diesel and gasoline type combustion are covered by explicit approaches supported by testbed data. The impact of the thermodynamic characteristics induced by the different fuels is described by an appropriate set of transport equations in combination with specifically prepared property databases. A thermodynamic highly accurate 6-species approach is presented. Additionally, a 3-species and a 1-species transport approach relying on the assumption of a lumped fuel are investigated regarding accuracy and computational performance. The comparison of measured and simulated pressure and temperature traces shows very good agreement. The real-time factor of a 6 cylinder medium speed engine is in the range of 0.2 for all species transport approaches, enabling the support of HiL based function development and calibration.