This paper presents an investigation of Cylinder De-Activation (CDA) technology on the performance of big end bearings. A multi-physics approach is used in order to take into account more realistic dynamic loading effects on the tribological behavior. The power loss, minimum film thickness and maximum temperature of big end bearings have been calculated during maneuver pertaining to the New European Driving Cycle (NEDC). Results show that bearing efficiency runs contrary to efficiency gained through combustion and pumping losses. Under CDA mode, the power loss of big end bearings is more than the power loss under engine normal mode. The problem is predominant at higher engine speeds and higher Brake mean Effective Pressures (BMEP) in active cylinders. It is also observed that the minimum film thickness is reduced under the CDA mode. This can affect wear performance. In addition, same behavior is noted for the maximum temperature rise which is higher under CDA.