An improved aircraft assembly line incorporates fully automated robotic tool change. Ten machine tools, each with two onboard 6-axis robots, drill and fasten airplane structural components. The robots change 100% of the process tooling (drill bits, bolt anvils, hole probes, and nosepieces) to allow seamless transition across the entire range of hole and fastener sizes (3/16″-7/16″). To support required rate, total tool change time (including automatic calibration) is less than 80 seconds. This paper describes the robots and their end effector hardware, reliability testing, and simulations for both mechanical clearance and cycle time estimation.