To improve the vehicle NVH performance and reduce the vibration of the exhaust system, average driving DOF displacement (ADDOFD) and dynamic analysis are used to optimize hanger locations. Based on the finite element model and rigid-flexible coupling model, exhaust system analysis model was established. According to the finite element model of the exhaust system, the free-free modal analysis is carried out, and the position of the hanging point of the exhaust system is optimized by using the ADDOFD method. Furthermore, through the dynamics analysis, the force of each hanger to the body is calculated by the dynamic analysis, then verify the rationality of the hanging position. The combination of the two methods can effectively determine the better NVH performance of the exhaust system with hanger locations in the earlier vehicle development process.