Prior research on assessing multiple inlet and outlet mufflers is limited, and only recently have researchers begun to consider suitable metrics for multiple inlet and outlet mufflers. In this paper, transmission loss and insertion loss are defined for multiple inlet and outlet mufflers using a superposition method that can be extended to any m-inlet n-outlet muffler. Transmission loss is determined assuming that the sources and terminations are anechoic. On the other hand, insertion loss considers reflections. For both metrics, the amplitude and phase relationship between the sources should be known a priori. This paper explains both metrics, and measurement of transmission and insertion loss are demonstrated for a 2-inlet 2-outlet muffler with good agreement.