Published information on studies of something so critical to safety as passenger vehicle tire pressures can be found [1, 2]; however, they only account for rolling tires. Studies related to spare tire pressures are lacking. This paper is the result of measurements on 150+ vehicles and the most surprising results are presented regarding the influence of Tire Pressure Monitoring Systems (TPMS) and the new spare tire locations and use. A statistical study was performed on the collected data to determine the correlation between tire pressures, vehicle age and TPMS. One particular topic of investigation was the relationship between various factors that influence spare tire pressure. Some newer models, particularly some mini-vans, have placed the spare tire in an unusual and inconvenient place for regular maintenance. Based on the data collected, TPMS has a positive influence on rolling tires but not on spare tires. The results support the need for TPMS to also monitor spare tire pressures.